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Non-Hodgkin's Lymphoma of the Orbit and Ocular Adnexa: Clinical Analysis of 22 Cases / 대한혈액학회지
Article em Ko | WPRIM | ID: wpr-720379
Biblioteca responsável: WPRO
ABSTRACT
BACKGROUND: Non-Hodgkin's lymphoma presenting in the eye is a rare disorder. The aim of this study was to evaluate the clinical features, treatment outcome and complications of patients with non-Hodgkin's lymphoma of the eye. METHODS: We designed retrospective, observational case study. The participants included 22 consecutive patients with non-Hodgkin's lymphoma of the orbit and ocular adnexa treated at the Yeungnam University Hospital between 1992 and 2001. RESULTS: There were 16 males (73%) and 6 females (27%). The median age at ocular presentation was 47. The most common presenting complaint was slowly growing mass at the eye. Histopathologic studies revealed extranodal marginal zone B-cell lymphoma, MALT type in 19 cases (86%), B-cell small lymphocytic lymphoma in one case, diffuse large B-cell lymphoma in one case, and lymphoplasmacytoid lymphoma/immunocytoma in one case. The stages of lymphomas were IA(E) in 17 cases (82%), IIA(E) in 2 cases (9%), IIIA(E) in 2 cases (9%). Radiotherapy alone was employed in 17 cases, chemoradiotherapy was done in 3 cases, chemotherapy alone was administered in one case. Nineteen out of 21 cases (90%) achieved a complete remission, and 5 year survival rate was approximately 90%. Subgroup analysis of the patients with lymphomas in stage IA(E) revealed that complete response rate was 100% and 5 year survival rate was 100% CONCLUSION: Radiotherapy alone can produce durable remission in the majority of the patients with localized extranodal marginal zone B-cell lymphoma, MALT type. However, combination chemotherapy or chemoradiotherapy should be considered in the patients with aggressive lymphomas or indolent lymphomas with systemic manifestation.
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Texto completo: 1 Índice: WPRIM Assunto principal: Órbita / Radioterapia / Linfoma não Hodgkin / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Taxa de Sobrevida / Estudos Retrospectivos / Linfoma de Células B / Resultado do Tratamento / Linfoma de Zona Marginal Tipo Células B Tipo de estudo: Observational_studies Limite: Female / Humans / Male Idioma: Ko Revista: Korean Journal of Hematology Ano de publicação: 2001 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Órbita / Radioterapia / Linfoma não Hodgkin / Linfócitos B / Leucemia Linfocítica Crônica de Células B / Taxa de Sobrevida / Estudos Retrospectivos / Linfoma de Células B / Resultado do Tratamento / Linfoma de Zona Marginal Tipo Células B Tipo de estudo: Observational_studies Limite: Female / Humans / Male Idioma: Ko Revista: Korean Journal of Hematology Ano de publicação: 2001 Tipo de documento: Article