Aggressive Systemic Mastocytosis Following Ovarian Germ Cell Tumor
Korean Journal of Hematology
;
: 129-133, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-720495
ABSTRACT
A 4 years-old girl was diagnosed with aggressive systemic mastocytosis at 2 months after the end of chemotherapy including cisplatin, bleomycin and etoposide for an ovarian germ cell tumor (GCT). She was shown pigmented skin lesion, hepatosplenomegaly, thrombocytopenia and increased mast cells with positive toluidine blue staining on the bone marrow examination. Immunohistochemical staining for c-kit was highly expressed in the bone marrow and skin, but not in the GCT specimen. However, c-kit point mutation was detected in the bone marrow, peripheral blood and GCT tissue when performing PCR via oligonucleotide sequencing. We report here on one case of aggressive systemic mastocytosis following ovarian germ cell tumor with c-kit point mutation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Trombocitopenia
/
Cloreto de Tolônio
/
Bleomicina
/
Medula Óssea
/
Exame de Medula Óssea
/
Reação em Cadeia da Polimerase
/
Cisplatino
/
Mutação Puntual
/
Neoplasias Embrionárias de Células Germinativas
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2005
Tipo de documento:
Artigo
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