Bortezomib Therapy Followed by Autologous Stem Cell Transplantation in POEMS Syndrome
Korean Journal of Hematology
;
: 145-149, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-720518
ABSTRACT
BACKGROUND:
The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. Increased levels of cytokines, including vascular endothelial growth factor (VEGF), appear to play a pathogenic role. POEMS syndrome is progressive and eventually leads to death from neurological problem without therapy.METHODS:
We treated 3 patients affected by POEMS syndrome with front-line bortezomib treatment and the high-dose melphalan with autologous stem cell transplantation (ASCT).RESULTS:
Bortezomib reduced circulating levels of VEGF in sera. After a median follow-up of 18 months (range, 16~20), all patients are alive with progressive improvement in neurological disease, skin changes, performance status and have no evidence of clonal plasmacytosis or organomegaly.CONCLUSION:
ASCT following bortezomib treatment may be a potential treatment option for patients with POEMS syndrome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polineuropatias
/
Pirazinas
/
Pele
/
Dermatopatias
/
Células-Tronco
/
Ácidos Borônicos
/
Seguimentos
/
Citocinas
/
Síndrome POEMS
/
Doenças do Sistema Nervoso Periférico
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hematology
Ano de publicação:
2008
Tipo de documento:
Artigo
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