A Case of Bone Marrow Involvement of Hepatosplenic gamma delta-Cell Lymphoma / 대한혈액학회지
Korean Journal of Hematology
;
: 134-137, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-720546
ABSTRACT
Hepatosplenic gamma delta-cell lymphoma is a rare histologic type of peripheral T-cell lymphomas, clinically characterized by predominant involvement of liver and spleen, no or little adenopathy, and an often aggressive course. We report a case of bone marrow involvement of hepatosplenicgamma delta-cell lymphoma in a 21- year-old woman who presented with fever, anemia, thrombocytopenia, and hepatosplenomegaly. A lymphoma was found subsequently by bone marrow biopsy and computed tomography scan of the abdomen and pelvis. Immunologic characterization of lymphoma cells in bone marrow revealed positivity for CD2, CD3, and CD16/56, and negativity for CD4, CD5, CD7, CD8, CD34, and terminal deoxynucleotidyl transferase (TdT). Conventional cytogenetic studies revealed the presence of isochromosome 7q. Using the PCR-SSCP technique, monoclonal gene rearrangement of the T-cell receptor gamma chain was demonstrated. Thus, we could make a confirmatory diagnosis as hepatosplenic gamma delta-cell lymphoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pelve
/
Baço
/
Trombocitopenia
/
Biópsia
/
Medula Óssea
/
Receptores de Antígenos de Linfócitos T
/
Rearranjo Gênico
/
Linfoma de Células T Periférico
/
Isocromossomos
/
Citogenética
Tipo de estudo:
Estudo diagnóstico
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2002
Tipo de documento:
Artigo
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