A Case of Primary Bone Lymphoma with Multifocal Bone Involvement / 대한혈액학회지

ABSTRACT

Primary bone lymphoma is a rare tumor accounting for only 5% of all primary osseous malignancies, defined as lymphoma which arises in the medullary cavity and there is no concurrent regional lymph node or visceral involvement. We experienced a case of primary bone lymphoma presented with multifocal bone involvemnt in a 30-year-old woman. She was admitted with 2-month-history of pain on the lower back and the right hip. On laboratory examination, pancytopenia was demonstrated. Radiologic studies showed multiple soft tissue masses that had destroyed the involved bones. The tissue section from bone marrow biopsy was positive for leukocyte common antigen and pan T-cell marker (UCHL-1) in the large malignant cells. The diagnosis of malignant lymphoma, diffuse large cell (T-cell phenotype) was made. On physical examination, pheripheral lymph nodes could not be palpable. Involvement of either regional lymph nodes or visceral organs could not be detected by radiological examinations including CT and Ga-67 scan. After the patient recieved 2 cycles of combination chemotheraphy with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) regimen, complete remission was achieved. Eight cycles of the chemotherapy were successfully completed.