Glutathione S-Transferase (GST) Gene Deletions in Korean Patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome / 대한혈액학회지
Korean Journal of Hematology
;
: 265-269, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-720827
ABSTRACT
BACKGROUND:
There have been many studies on the association between the glutathione S- transferase (GST) genotype and the susceptibility to acute myeloid leukemia (AML)/myelodysplastic syndrome (MDS) and the results are still controversial. We tested whether the homozygous null genotype of GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes influences the risk for MDS and AML.METHODS:
We analyzed bone marrow DNA samples from 54 patients with AML or MDS (14 de novo AML, 7 secondary AML, and 33 MDS) and peripheral blood DNA samples from 75 cancer-free controls. The GSTM1 and GSTT1 genotypes were analyzed by multiplex polymerase chain reaction (PCR).RESULTS:
The frequencies of GSTM1 null and GSTT1 null were not significantly increased in AML/MDS cases compared with those in controls.CONCLUSION:
Our data suggest that GSTM1 and GSTT1 null genotypes may not predispose to AML/MDS in Korean population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transferases
/
Medula Óssea
/
Síndromes Mielodisplásicas
/
DNA
/
Leucemia Mieloide Aguda
/
Deleção de Genes
/
Reação em Cadeia da Polimerase Multiplex
/
Genótipo
/
Glutationa
/
Glutationa Transferase
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Hematology
Ano de publicação:
2002
Tipo de documento:
Artigo
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