A case of donor-derived granulocytic sarcoma after allogeneic hematopoietic stem cell transplantation
Korean Journal of Hematology
;
: 70-72, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-721023
ABSTRACT
The occurrence of granulocytic sarcoma as a pattern of relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rare. In this paper, we report a rare case of acute myeloid leukemia (AML) relapsed as a granulocytic sarcoma of the donor type. The patient was diagnosed as having AML and underwent an allo-HSCT from his matched sibling donor. Fifty-seven months after allo-HSCT, he developed granulocytic sarcomas of duodenum, jejunum, and left sterno-cleido-mastoid muscle. The bone marrow was normal with 100% donor chimerism. A Y chromosome PCR was performed on the patient's duodenum specimen as well as bone marrow aspirate in order to check the patient-origin cells. The duodenal specimen was found to contain 41.2% SRY-positive cells (from the donor). Repeat endoscopy on day 2 of chemotherapy showed that the granulocytic sarcoma had shrunk dramatically. The patient died of sepsis during the nadir state 35 days after starting salvage chemotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Doadores de Tecidos
/
Cromossomo Y
/
Medula Óssea
/
Células-Tronco Hematopoéticas
/
Leucemia Mieloide Aguda
/
Reação em Cadeia da Polimerase
/
Sepse
/
Transplante de Células-Tronco Hematopoéticas
/
Sarcoma Mieloide
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hematology
Ano de publicação:
2010
Tipo de documento:
Artigo
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