Clinical Significance of von Willebrand Factor-Cleaving Protease (ADAMTS13) Deficiency in Patients with Sepsis-Induced Disseminated Intravascular Coagulation / 감염과화학요법
Infection and Chemotherapy
;
: 78-81, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-721866
ABSTRACT
BACKGROUND:
Deficiency of von Willebrand factor-cleaving protease, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13), is thought to be responsible for platelet aggregation and microthrombi formation, which in turn cause typical thrombotic microangiopathies. This deficiency is found in patients with thrombocytopenia-associated multiple organ failure such as thrombocytopenic purpura and disseminated intravascular coagulation (DIC). We evaluated the clinical significance of ADAMTS13 deficiency in patients with sepsis-induced DIC. MATERIALS ANDMETHODS:
Nineteen patients with sepsis-induced DIC were enrolled. ADAMTS13 antigen levels were determined by Enzyme-Linked Immunosorbent Assay (ELISA) and activity levels were measured by fluorescence resonance energy transfer assay. Patients were categorized into two groups according to ADAMTS13 antigen level less than 350 ng/mL or above. Clinical characteristics and survival were compared between the two groups.RESULTS:
ADAMTS13 antigen level was less than 350 ng/mL in 7 patients and was above 350 ng/mL in 12 patients. There were no significant differences between the groups for age, sex, severity of illness, and other clinical characteristics. In patients with ADAMTS13 antigen level less than 350 ng/mL, in-hospital mortality was much higher (100% versus 25%, P=0.003) and 7-day survival was much shorter (P=0.023).CONCLUSION:
Deficiency of ADAMTS13 could be thought to be associated with unfavorable outcome in patients with sepsis-induced DIC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Púrpura Trombocitopênica
/
Ensaio de Imunoadsorção Enzimática
/
Agregação Plaquetária
/
Mortalidade Hospitalar
/
Sepse
/
Trombospondinas
/
Dacarbazina
/
Transferência Ressonante de Energia de Fluorescência
/
Coagulação Intravascular Disseminada
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Infection and Chemotherapy
Ano de publicação:
2009
Tipo de documento:
Artigo
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