Evaluation of a New Diagnostic Test for Invasive Fungal Infections Using Prophenoloxydase System to Measure (1->3)-beta-D-glucan Concentration / 감염과화학요법
Infection and Chemotherapy
;
: 146-153, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-721981
ABSTRACT
BACKGROUND:
Prognosis of invasive fungal infection is supposed to be better when diagnosed earlier. (1->3)-beta-D-glucan (BDG) test is considered useful in early diagnosis of invasive fungal infections among high-risk patients. A new diagnostic test using prophenoloxydase system to measure BDG level is developed. A study was performed to evaluate clinical usefulness of this new diagnostic test. MATERIALS ANDMETHODS:
15 patients of confirmed invasive fungal infections and 38 healthy normal volunteers were enrolled. Plasma or serum BDG concentrations were measured using prophenoloxydase system. Assays for intra-run variability and inter-run variability were performed. A cut-off value was determined and sensitivity and specificity of the test were evaluated.RESULTS:
A cut-off value of 94.90 pg/mL was determined. Sensitivity and specificity of the test were 86.7% and 52.6%, respectively. Statistical analyses of inter-run variability and intra-run variability revealed the test is reliable (P< or =0.001).CONCLUSION:
BDG test using prophenoloxydase system is a sensitive and reliable test in non-invasive detection of invasive fungal infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Prognóstico
/
Sensibilidade e Especificidade
/
Diagnóstico Precoce
/
Testes Diagnósticos de Rotina
/
Voluntários Saudáveis
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Coreano
Revista:
Infection and Chemotherapy
Ano de publicação:
2006
Tipo de documento:
Artigo
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