Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review / 감염과화학요법
Infection and Chemotherapy
; : 153-159, 2018.
Article
em En
| WPRIM
| ID: wpr-721993
Biblioteca responsável:
WPRO
ABSTRACT
Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteínas Tirosina Quinases
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Ganciclovir
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Reação em Cadeia da Polimerase
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Resultado do Tratamento
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Colite
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Neoplasias Hematológicas
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Citomegalovirus
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Diarreia
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Leucemia-Linfoma Linfoblástico de Células Precursoras
Limite:
Humans
Idioma:
En
Revista:
Infection and Chemotherapy
Ano de publicação:
2018
Tipo de documento:
Article