Effects of Enriched Environment on Locomotion and Cognition in Neonatal Rats with Hypoxic-Ischemic Encephalopathy
Journal of the Korean Academy of Rehabilitation Medicine
; : 1-9, 2010.
Article
em Ko
| WPRIM
| ID: wpr-723101
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model. METHOD: Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared. RESULTS: The neurobehavioral tests of the rats with hypoxic-ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p<0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p<0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p<0.05). CONCLUSION: The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Oxigênio
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Logro
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Encéfalo
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Artérias Carótidas
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Inalação
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Ratos Sprague-Dawley
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Cognição
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Hipóxia-Isquemia Encefálica
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Espinhas Dendríticas
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Extremidades
Limite:
Animals
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Humans
Idioma:
Ko
Revista:
Journal of the Korean Academy of Rehabilitation Medicine
Ano de publicação:
2010
Tipo de documento:
Article