Effects of Bone Density as Injections of Salmon Calcitonin Micropheres in Ovariectomized Rats

ABSTRACT

OBJECTIVE: This study was evaluated the bone protective effects of the salmon calcitonin microspheres against the cancellous bone loss in the ovariectomized rats. METHOD: The experimented rats were total 50 Sprague-Dawley female rats. They were divided randomly 5 groups. The treatment was initiated on the first day after surgery and continued for a period of 4 weeks. Bone measurements were performed in the distal femoral metaphysis and 5th lumbar vertebrae with dual energy x-ray absorptiometry at the time of 2nd week and 4th week after drug injection in all groups. RESULTS: The cancellous bone density in the ovariectomized rats treated with high dose of the salmon calcitonin microspheres was significantly higher than that of the free salmon calcitonin-treated ovariectomized rats, but less than that of the sham-operated control rats. CONCLUSION: This study shows that the salmon calcitonin microspheres were evaluated for protection against the can cellous bone loss in the ovariectomized rats. The bone protective effect of the salmon calcitonin microspheres was greater than that of the free salmon calcitonin.