H MR Spectroscopy on Parkinson's-like Syndrome Induced by Manganese Intoxication: A Case Report

ABSTRACT

Manganese intoxificaton is a well-known cause of Parkinson's like syndrome. We describe a 46-year-old man who had been occupationally exposed to manganese and report the case with hydrogen magnetic resonance spectroscopy (1H MRS). Ratios of N-acetyl-aspartate (NAA) to creatine were significantly reduced in basal ganglia regions compared to normal subjects. The level of NAA was decreased in basal ganglia regions may indicate neuronal dysfunction. 1H MRS can provide detailed information of brain damage, therefore the 1H MRS is very useful in diagnosis of manganese intoxification.