Multiple Symmetric Lipomatosis with Peripheral Neuropathy: A case report
Journal of the Korean Academy of Rehabilitation Medicine
;
: 622-626, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-724618
ABSTRACT
Multiple symmetric lipomatosis is a rare disorder characterized by massive fatty deposits arranged symmetrically around the neck, shoulder, abdomen and back. It is typically associated with high alcohol consumption and a high prevalence of peripheral neuropathy. The pathogenesis of the syndrome is still unknown, but mitochondrial abnormality or metabolic abnormalities are occasionally found in the affected patients. In our patient, clinical and electrophysiologic signs of a generalized peripheral sensorimotor neuropathy and a multiple bilateral lumbosacral radiculopathy were observed. Sural nerve biopsy demonstrated many small unmyelinated fibers with complete loss of axoplasm and a extensive loss of myelinated fibers. Lipoma biopsy demonstrated non-capsulated mature adipose cells in the subcutaneous tissue. Serum lipid studies were normal. MERRF point mutation of mitochondrial DNA were negative in blood. We reported a case of multiple symmetric lipomatosis and peripheral polyneuropathy with the review of literature.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polineuropatias
/
Radiculopatia
/
Ombro
/
Nervo Sural
/
Biópsia
/
Lipomatose Simétrica Múltipla
/
Consumo de Bebidas Alcoólicas
/
DNA Mitocondrial
/
Prevalência
/
Mutação Puntual
Tipo de estudo:
Estudo de prevalência
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Academy of Rehabilitation Medicine
Ano de publicação:
2004
Tipo de documento:
Artigo
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