Effect of Antipsychotic Drugs on Dopamine Transporter Function in CV(bDAT) Cells
Journal of the Korean Society of Biological Psychiatry
;
: 48-53, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-724916
ABSTRACT
CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake were investigated. All of antipsychotic drugs tested, inhibited the [3>H]dopamine uptake into CV(bDAT) cells with IC50s in the low to mid micromolar, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antipsicóticos
/
Transfecção
/
Dopamina
/
Linhagem Celular
/
DNA Complementar
/
Concentração Inibidora 50
/
Proteínas da Membrana Plasmática de Transporte de Dopamina
/
Neurônios Dopaminérgicos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
1997
Tipo de documento:
Artigo
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