Allelic Association of the Dopamine D4 Receptor Gene in Korean Alcoholism
Journal of the Korean Society of Biological Psychiatry
;
: 246-250, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-724924
ABSTRACT
The dopamine D4 receptor gene has a hypervariable segment in the coding region charcterized by a varying number of 48bp repeats in exon III of the gene. Varying the numbers of repeated segments may change the length, structure, and function of the receptor, which makes this gene a possible candidate for variations in dopamine-related behaviors. such as alcoholism and drug abuse. We evaluated the dopamine D4 receptor genotype in male alcoholics and normal controls. All alcoholics and controls were unrelated and from the Korean population. Genotype and allele frequencies in 67 alcoholics were compared to 67 controls who were free of alcohol abuse. substance abuse. and major mental illness. No association was found between the dopamin D4 recepto allele and alcoholism. This result indicate that there is no association of the dopamine D4 receptor with alcoholism in Korean. Further systemized investigation to determine the role of dopamine D4 receptor gene in alcoholism with a larger sample size will be required.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dopamina
/
Éxons
/
Tamanho da Amostra
/
Transtornos Relacionados ao Uso de Substâncias
/
Alcoolismo
/
Alelos
/
Receptores de Dopamina D4
/
Alcoólicos
/
Codificação Clínica
/
Frequência do Gene
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2001
Tipo de documento:
Artigo
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