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Relationship of Estrogen to Extrapyramidal Symptoms in Female Schizophrenic Patients
Journal of the Korean Society of Biological Psychiatry ; : 147-152, 2001.
Artigo em Coreano | WPRIM | ID: wpr-724977
ABSTRACT

OBJECTIVE:

It has been thought that estrogen has neuroleptic like effect in women schizophrenic patients. This study aimed to investigate neuroleptic side-effects severity in women with schizohrenia and to investigate their putative association with variations in sex steroids over menstrual cycle. Based on the estrogen theory, The author hypothesized that parkinsonian side-effects would be exacerbated when estrogen levels were high.

METHOD:

26 schizophrenic women were assessed using the ESRS(Extrapyramidal Symptom Rating Scale) and estrogen analysis. Tests were conducted twice, in the mid luteal and mid follicular phase.

RESULT:

It was hypothesized that high level of estrogen would lead to an exacerbation of parkisonian side-effects but the results indicated that parkinsonian side effects decreased overall when estrogen levels were high. This effects were more marked for the group taking typical neuroleptics than those taking atypical neuroleptics.

CONCLUSION:

The results of this study suggest that estrogen and progesteron may reduce the severity of neuroleptic indeced extrapyramidal side effects over menstrual cycle in women with schizophrenia. It was concluded that estrogen has different effects on dopamine dynamics in the mesolimbic and mesostriatal pathways according to estrogen, progesteron, catecol estrogen, prolactine.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prolactina / Esquizofrenia / Esteroides / Antipsicóticos / Dopamina / Estrogênios / Fase Folicular / Ciclo Menstrual Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of the Korean Society of Biological Psychiatry Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prolactina / Esquizofrenia / Esteroides / Antipsicóticos / Dopamina / Estrogênios / Fase Folicular / Ciclo Menstrual Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of the Korean Society of Biological Psychiatry Ano de publicação: 2001 Tipo de documento: Artigo