The Association between Polymorphism of the Dopamine D3 Receptors and Concentrations of Plasma Homovanillic and 5-hydroxyindoleacetic Acid, and Therapeutic Response of chronic Schizophrenic Patients
Journal of the Korean Society of Biological Psychiatry
;
: 116-122, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-724981
ABSTRACT
OBJECTIVES:
Schizophrenia manifests a variety of interindividual differences in therapeutic response to antipsychotics. This might be attributable to dopamine and serotonin receptors that a important target for various antipsychotics, and the D3 receptor(DRD3) alleles they carry. The purpose of our study was to investigate whether the plasma levels of homovanillic acid(HVA) and 5-hydroxyindoleacetic acid(HIAA), and the polymorphism of DRD3 can be held as a predictor of treatment response ni chronic schizophrenic patients.METHODS:
Therapeutic response for 16 korean schizophrenia patient treated during 48 weeks were assessed by PANSS used as the clinical symptom rating scales. The levels of concentration of HVA and 5-HIAA were examined by HPLC at baseline and at 48 weeks. We classified the polymorphism of DRD3 receptor using amplifying by polymerase chain reaction(PCR).RESULTS:
Neither concentrations of HVA and 5-HIAA nor genotype of dopamine 3 receptor were not significantly associated with the therapeutic response. But, the patients who has A1 alleles of DRD3 gene showed poor therapeutic responses.CONCLUSION:
A1 allele of DRD3 gene is associated with poor prognosis of chronic schizophrenia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Prognóstico
/
Esquizofrenia
/
Antipsicóticos
/
Pesos e Medidas
/
Dopamina
/
Cromatografia Líquida de Alta Pressão
/
Receptores de Serotonina
/
Alelos
/
Receptores de Dopamina D3
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2001
Tipo de documento:
Artigo
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