No Association between the 5-HT6 Receptor C267T Polymorphism and Response to Citalopram Treatment in Patient with Major Depressive Disorder
Journal of the Korean Society of Biological Psychiatry
;
: 262-267, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-725084
ABSTRACT
The serotonin 6(5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder(MDD). METHODS:
Citalopram was administered for 8 weeks to the 90 patients who completed study. 21-item Hamilton depression rating scale(HAMD-21) was used as a outcome measure.RESULTS:
We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.CONCLUSIONS:
These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with the treatment response to citalopram.
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Índice:
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Assunto principal:
Citalopram
/
Serotonina
/
Avaliação de Resultados em Cuidados de Saúde
/
Depressão
/
Transtorno Depressivo Maior
/
Alelos
/
Genótipo
/
Antidepressivos
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2007
Tipo de documento:
Artigo
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