Other N-Methyl-D-Aspartate (NMDA) Receptor Antagonists with a Rapid Onset of Action and Less Side Effect in the Treatment of Depression
Journal of the Korean Society of Biological Psychiatry
; : 149-154, 2015.
Article
em Ko
| WPRIM
| ID: wpr-725356
Biblioteca responsável:
WPRO
ABSTRACT
Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. Many prescribed antidepressants modulate monoamine neurotransmitters including serotonin, norepinephrine and dopamine. There has been greater focus on the major excitatory neurotransmitter in the human brain, glutamate, in the pathophysiology and treatment of major depressive disorder (MDD). Recently, ketamine, an N-methyl-D-aspartate receptor antagonist, has received attention and has been investigated for clinical trials and neurobiological studies. In this article, we will review the clinical evidence for glutamatergic dysfunction in MDD, the progress with ketamine as a rapidly acting antidepressant, and other N-methyl-D-aspartate receptor antagonist for treatment-resistant depression.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Encéfalo
/
Dopamina
/
Serotonina
/
Norepinefrina
/
Prevalência
/
N-Metilaspartato
/
Neurotransmissores
/
Ácido Glutâmico
/
Transtornos do Humor
/
Depressão
Tipo de estudo:
Prevalence_studies
Limite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2015
Tipo de documento:
Article