Primary structure of mature SAG1 gene of an Indonesian Toxoplasma gondii and comparison with other strains
Journal of Veterinary Science
;
: 263-270, 2006.
Artigo
em Inglês
| WPRIM
| ID: wpr-72556
ABSTRACT
Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrates. SAG1 (p30) is the prototypic member of a superfamily of surface antigens called SRS (SAG1-related sequence). It constitutes the most abundant and predominant antigen. In this paper the primary structure of mature SAG1 gene of an Indonesian T. gondii isolate is described and sequence comparison is made with published sequence data of 7 other strains or isolates. Sequence comparison indicated that SAG1 is highly conserved through evolution and despite parasite spreading world-wide. Sequences may be divided into two major families, independent of the strain/isolate geographic origin. Variations were mainly localized at the C-terminal half or domain 2 and some clustered in restricted areas. Sequence comparison allowed us to define the Indonesian isolate as genuine virulent RH strain. A phylogenetic tree of Toxoplasma strains/isolates was constructed based on SAG1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Toxoplasma
/
Cabras
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Zoonoses
/
Doenças das Cabras
/
Proteínas de Protozoários
/
Toxoplasmose
/
Reação em Cadeia da Polimerase
Limite:
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Veterinary Science
Ano de publicação:
2006
Tipo de documento:
Artigo
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