Cytologic Evaluation of Adenocarcinoma and its Mimics in Sputum and Bronchial Washings / 대한세포병리학회지
Korean Journal of Cytopathology
; : 36-45, 2007.
Article
em Ko
| WPRIM
| ID: wpr-726231
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To identify key cytologic features for diagnosis of adenocarcinoma and morphologic differentiation from reactive/reparative respiratory epithelium. STUDY DESIGN: The cytomorphologic features of 145 pulmonary cytology specimens (sputum and bronchial washing), which included 117 histologically proven adenocarcinomas and 28 non-neoplastic lesions, cytologically diagnosed as atypia and suspicious for malignancy (adenocarcinoma) were reviewed retrospectively. We analyzed 11 morphologic criteria in pulmonary cytologic specimens. RESULTS: Over 110 of 117 cases of adenocarcinomas revealed nuclear membrane irregularities, non-cohesive cells, single atypical cells, moderate to markedly enlarged nuclei and an increased nuclear/cytoplasmic (N/C) ratio. Chromatin clearing, chromatin heterogeneity and hyperchromasia were seen in 102, 99 and 97 cases, respectively. All 28 cases involving non-neoplastic lesions revealed hyperplastic reactive pneumocytes, hyperplastic reactive bronchial epithelium, or degenerating macrophages. The non-neoplastic lesions revealed a small number of atypical cell clusters and paucity or absence of atypical single cells. CONCLUSION: The most important morphologic features for diagnosis of adenocarcinoma are nuclear membrane irregularities, non-cohesive cells, single atypical cell, moderate to markedly enlarged nuclei and increased N/C ratio. Chromatin clearing, chromatin heterogeneity and hyperchromasia were also helpful features, while pleomorphism and prominent nucleoli were less valuable.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Escarro
/
Características da População
/
Cromatina
/
Adenocarcinoma
/
Estudos Retrospectivos
/
Mucosa Respiratória
/
Diagnóstico
/
Epitélio
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Células Epiteliais Alveolares
/
Pulmão
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Idioma:
Ko
Revista:
Korean Journal of Cytopathology
Ano de publicação:
2007
Tipo de documento:
Article