Detection of Epstein-Barr virus in the inflammatory and neoplastic uterine cervical lesions / 대한세포병리학회지
Korean Journal of Cytopathology
;
: 73-80, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-726343
ABSTRACT
The prevalence of Epstein-Barr virus(EBV) in the uterine cervix was investigated to define the possible etiologic role in cervical carcinogenesis. The viral genotyping and LMP-1 30bp deletion were also studied. The materials included 169 uterine cervical swabs(152 within normal limits, 12 atypical squamous cells of uncertain significance, 3 low grade intraepithelial lesions, and 2 high grade squamous intraepithelial lesion) and 104 uterine cervical tissues obtained from hysterectomy specimens(32 carcinoma in situ, 9 microinvasive squamous cell carcinomas, 37 invasive squamous cell carcinomas, 7 adenocarcinomas, 7 adenosquamous carcinomas, and 12 cervicitis). EBV detected by PCR for EBNA-1 was positive in 52(56.5%) of 92 invasive and noninvasive cervical carcinomas, and 80(48.8%) of 164 inflammatory or normal cervices. The viruses detected in carcinomas were all type A, and LMP-1 30bp deletion form was more frequent in premalignant and malignant cervical lesions than in nonneoplastic cervices. From the above results, it may be concluded that EBV is one of common viruses detected in uterine cervix of Korean women, and type A virus and LMP-1 30bp deletion form may have a role in cervical carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Carcinoma in Situ
/
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Colo do Útero
/
Reação em Cadeia da Polimerase
/
Prevalência
/
Carcinoma Adenoescamoso
/
Herpesvirus Humano 4
/
Carcinogênese
/
Genótipo
Tipo de estudo:
Estudo diagnóstico
/
Estudo de prevalência
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Cytopathology
Ano de publicação:
2001
Tipo de documento:
Artigo
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