Diabetes and Endocrine Disease / 임상당뇨병
Journal of Korean Diabetes
;
: 155-159, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-727034
ABSTRACT
Impaired insulin secretion and insulin resistance are the two main mechanisms leading to type 2 diabetes mellitus. Insulin exerts multiple effects upon target cells, especially skeletal muscle, liver, and adipose tissue. In general, insulin promotes storage of glucose and inhibits the breakdown of stored glycogen into glucose. The counter regulatory hormones glucagon, catecholamine, cortisol and growth hormone are released during hypoglycemia and under other stress conditions. These hormones have insulin-antagonistic effects both in the liver and in the peripheral tissues. A significant number of endocrine disorders is associated with varying degrees of glucose intolerance, with which sustained excess of these hormones is associated. Indeed, type 2 diabetes is frequently observed in patients with various hormonal diseases including acromegaly, Cushing syndrome, pheochromocytoma, hyperthyroidism, and glucagonoma. In particular, improvement of glycemic control following treatment for these hormonal diseases confirms a causal relationship between excess of these hormones and diabetes. In this review, there will be a discussion over these endocrine diseases in relation to diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Feocromocitoma
/
Acromegalia
/
Resistência à Insulina
/
Glucagon
/
Hidrocortisona
/
Hormônio do Crescimento
/
Tecido Adiposo
/
Intolerância à Glucose
/
Músculo Esquelético
/
Síndrome de Cushing
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Diabetes
Ano de publicação:
2017
Tipo de documento:
Artigo
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