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Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice
Nutrition Research and Practice ; : 227-234, 2015.
Artigo em Inglês | WPRIM | ID: wpr-72726
ABSTRACT
BACKGROUND/

OBJECTIVES:

We investigated the effects of a combination of grape pomace (Vitis labrusca, Campbell Early) and Omija fruit (Schizandra chinensis, Baillon) ethanol extracts on lipid metabolism and antioxidant defense system in diet-induced obese mice. MATERIALS/

METHODS:

Forty male C57BL/6J mice were divided into four groups and fed high-fat diet (control group, CON) or high-fat diet added 0.5% grape pomace extract (GPE), 0.05% Omija fruit extract (OFE) or 0.5% GPE plus 0.05% OFE (GPE+OFE) for 12 weeks.

RESULTS:

In contrast to the GPE- or OFE-supplemented groups, the GPE+OFE group showed significantly lower body weight and white adipose tissue weights than the CON group. Moreover, GPE+OFE supplementation significantly decreased plasma total cholesterol and increased the plasma HDL-cholesterol/total-cholesterol ratio (HTR) compared to the control diet. The hepatic triglyceride level was significantly lower in the GPE+OFE and GPE groups by increasing beta-oxidation and decreasing lipogenic enzyme compared to the CON group. Furthermore, GPE+OFE supplementation significantly increased antioxidant enzyme activities with a simultaneous decrease in liver H2O2 content compared to the control diet.

CONCLUSIONS:

Together our results suggest that supplementation with the GPE+OFE mixture may be more effective in improving adiposity, lipid metabolism and oxidative stress in high-fat diet-fed mice than those with GPE and OFE alone.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Triglicerídeos / Pesos e Medidas / Peso Corporal / Colesterol / Estresse Oxidativo / Vitis / Dieta / Etanol / Adiposidade Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2015 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Plasma / Triglicerídeos / Pesos e Medidas / Peso Corporal / Colesterol / Estresse Oxidativo / Vitis / Dieta / Etanol / Adiposidade Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2015 Tipo de documento: Artigo