Coordinate expression of renin and cyclooxygenase-2 in rats with two-kidney, one clip and deoxycorticosterone acetate-salt hypertension
The Korean Journal of Physiology and Pharmacology
;
: 253-258, 2001.
Artigo
em Inglês
| WPRIM
| ID: wpr-727428
ABSTRACT
The present study was aimed to examine whether the expression of renin is associated with that of cyclooxygenase-2 (COX-2) in the kidney. Male Sprague-Dawley rats were made two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertensive, to stimulate or to inhibit the endogenous renin-angiotensin system, respectively. The expression of renin and COX-2 mRNA was determined in the cortex of the kidney by reverse transcription-polymerase chain reaction. 2K1C hypertensive rats showed an increased expression of renin as well as of COX-2 in the clipped kidney. The expression of renin was decreased in parallel with that of COX-2 in the contralateral non-clipped kidney. Removal of the renal arterial clip reversed the expression of both genes, along with the blood pressure, to the control level. On the other hand, DOCA-salt hypertension was associated with parallel decreases of renin and COX-2 expression. These results indicate that renin and COX-2 genes are coordinately expressed in the kidney.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema Renina-Angiotensina
/
Pressão Sanguínea
/
RNA Mensageiro
/
Renina
/
Ratos Sprague-Dawley
/
Desoxicorticosterona
/
Ciclo-Oxigenase 2
/
Mãos
/
Hipertensão
/
Rim
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2001
Tipo de documento:
Artigo
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