Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction
The Korean Journal of Physiology and Pharmacology
;
: 177-182, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-727678
ABSTRACT
This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction models were established in male Wistar rats after exposure to homocysteine (Hcy), high fat diet (HFD) and Hcy+HFD. The results showed that there was endothelial dysfunction in all three models with varying degrees. However, the expression of NEI network was totally different. Interestingly, treatment with simvastatin was able to improve vascular endothelial function and restored the imbalance of the NEI network, observed in the Hcy+HFD group. The results indicated that NEI network may have a strong association with endothelial function, and this relationship can be used to distinguish different risk factors and evaluate drug effects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores de Risco
/
Ratos Wistar
/
Sinvastatina
/
Sistema Endócrino
/
Dieta Hiperlipídica
/
Homocisteína
/
Sistema Imunitário
/
Sistema Nervoso
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2014
Tipo de documento:
Artigo
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