Selective cytotoxicity of a novel platinum(II) coordination complex on human bladder cancer cell lines and normal kidney cells
The Korean Journal of Physiology and Pharmacology
;
: 159-167, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-727742
ABSTRACT
We have synthesized a novel platinum(II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-dichloroethane (DCE) as a leaving group. In addition, nitrate was added to improve the water-solubility. A new series of (Pt(cis-DACH)(DCE)) cntdot 2NO3(PC) was evaluated for its cytotoxic activity on T-24 and J-82 human bladder carcinoma cells and normal primary cultured kidney cells. PC has demonstrated high levels of cytotoxicity against T-24 and J-82 cells. The cytotoxicity of PC against rabbit proximal renal tubular cells, human renal cortical cells and human renal cortical tissues, determined using the MTT assaying technique, the (3H)-thymidine uptake and glucose consumption tests, was found to be quite less than those of cisplatin. Based on these results, this novel platinum(II) coordination complex appears to be better for improving antitumor activities with low nephrotoxicity and is a valuable lead in the development of new clinically available anticancer chemotherapeutic agents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Linhagem Celular
/
Cisplatino
/
Glucose
/
Rim
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2000
Tipo de documento:
Artigo
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