Angiotensin-converting enzyme gene polymorphism is not associated with myocardial infarction in Koreans
The Korean Journal of Physiology and Pharmacology
; : 645-650, 1998.
Article
em En
| WPRIM
| ID: wpr-727751
Biblioteca responsável:
WPRO
ABSTRACT
To assess the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and myocardial infarction in Koreans, we recruited 112 healthy, unrelated subjects (mean age 53.4 years) and 104 myocardial infarction survivors (mean age 54.2 years) of both sexes. An insertion/deletion (IID) polymorphism of the ACE gene was typed by polymerase chain reaction. The I allelic frequency of ACE gene in Korean subjects was irrelevant to myocardial infarction (patients, 65%; control subjects 66%), as was true with the D allele. When compared with other populations, the frequency of D allele in Koreans (0.34) was lower than that in Caucasians, and was close to that of other Oriental populations. The data suggest that the ACE gene polymorphism is not an independent genetic risk factor for myocardial infarction in Koreans.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Reação em Cadeia da Polimerase
/
Fatores de Risco
/
Sobreviventes
/
Povo Asiático
/
Alelos
/
Infarto do Miocárdio
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
1998
Tipo de documento:
Article