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Effect of C1 esterase inhibitor on the cardiac dysfunction following ischemia and reperfusion in the isolated perfused rat heart
The Korean Journal of Physiology and Pharmacology ; : 579-586, 1999.
Artigo em Inglês | WPRIM | ID: wpr-727834
ABSTRACT
Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement-dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg) to I/R hearts in the presence of PMNs (100 X 106) and homologous plasma improved coronary flow and preserved cardiac contractile function (p<0.001) in comparison to those I/R hearts receiving only vehicle. In addition, C1 INH significantly (p<0.001) reduced PMN accumulation in the ischemic myocardium as evidenced by an attenuation in myeloperoxidase activity. These findings demonstrate the C1 INH is a potent and effective cardioprotective agent inhibits leukocyte-endothelial interaction and preserves cardiac contractile function and coronary perfusion following myocardial ischemia and reperfusion.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Plasma / Reperfusão / Traumatismo por Reperfusão / Complemento C1s / Isquemia Miocárdica / Peroxidase / Ativação de Neutrófilo / Proteína Inibidora do Complemento C1 / Coração Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 1999 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Plasma / Reperfusão / Traumatismo por Reperfusão / Complemento C1s / Isquemia Miocárdica / Peroxidase / Ativação de Neutrófilo / Proteína Inibidora do Complemento C1 / Coração Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 1999 Tipo de documento: Artigo