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Primary role of posterior hypothalamic cholinergic receptors in central regulation of blood pressure and heart rate in rats
The Korean Journal of Physiology and Pharmacology ; : 639-645, 1997.
Artigo em Inglês | WPRIM | ID: wpr-727968
ABSTRACT
The purpose of the present study is to determine the role of muscarinic cholinergic receptors of posterior hypothalamus in the central blood pressure regulation when respiration is controlled. In anesthetized and artificially ventilated rats, vasodepressor response was evoked by injection of L-glutamate (10 nmol) neuroexcitatory amino acid into the posterior hypothalamic area. The injection of carbachol (0.5 ~ 8 nmol) into the same area induced dose-dependent vasodepressor and bradycardic responses. Pretreatment with atropine (4 nmol) completely blocked the vasodepressor response to carbachol (2 nmol). In contrast, in spontaneously breathing rats, the injection of carbachol (8 nmol) into the posterior hypothalamic area induced the vasopressor and tachycardic responses. These results suyggest that the muscarinic cholinergic receptors in the posterior hypothalamic area primarily play an inhibitory role in the central regulation of blood pressure and heart rate.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Respiração / Atropina / Pressão Sanguínea / Carbacol / Receptores Colinérgicos / Receptores Muscarínicos / Ácido Glutâmico / Coração / Frequência Cardíaca / Hipotálamo Posterior Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 1997 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Respiração / Atropina / Pressão Sanguínea / Carbacol / Receptores Colinérgicos / Receptores Muscarínicos / Ácido Glutâmico / Coração / Frequência Cardíaca / Hipotálamo Posterior Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 1997 Tipo de documento: Artigo