Cholinergic activity related to cardiovascular regulation in rostral ventrolateral medulla of spontaneously hypertensive rats
The Korean Journal of Physiology and Pharmacology
;
: 29-34, 1999.
Artigo
em Inglês
| WPRIM
| ID: wpr-728036
ABSTRACT
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to clarify the mechanisms of cholinergic hyperactivity in RVLM of the SHR, we studied the activities of enzymes that participate in the biosynthesis and degradation of acetylcholine (ACh) and the density of muscarinic receptors in RVLM of the 14- to 18-week-old SHR and age-marched Wistar Kyoto rats (WKY). Choline acetyltransferase activity was far greater in RVLM of SHR than that of WKY. (3H)ACh release from RVLM was also greater in SHR than in WKY. Acetylcholinesterase activity and (3H)NMS binding of RVLM slice of SHR were not significantly different from that of WKY. These results suggest that the enhanced cholinergic mechanisms in the RVLM of SHR is due to the enhanced presynaptic cholinergic tone rather than the altered postsynaptic mechanisms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Acetilcolinesterase
/
Ratos Endogâmicos SHR
/
Ratos Endogâmicos WKY
/
Pressão Sanguínea
/
Acetilcolina
/
Colina O-Acetiltransferase
/
Receptores Muscarínicos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
1999
Tipo de documento:
Artigo
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