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Increased expression of nitric oxide synthases in left and right ventricular hypertrophy
The Korean Journal of Physiology and Pharmacology ; : 65-70, 2001.
Artigo em Inglês | WPRIM | ID: wpr-728113
ABSTRACT
The present study was aimed to explore pathophysiological implications of nitric oxide in the development of left and right ventricular hypertrophy. To induce selective left and right ventricular hypertrophy, rats were made two-kidney, one clip (2K1C) hypertensive and treated with monocrotaline (MCT), respectively. Six weeks later, the hearts were taken and their ventricular tissue mRNA and protein expression of endothelial constitutive isoform of nitric oxide synthase (NOS) were determined by reverse transcription-polymerase chain reaction and Western blot analysis, respectively. In 2K1C hypertensive rats, the expression of NOS mRNA was increased in parallel with its proteins in the left ventricle, but not in the right ventricle. In MCT-treated rats, the expression of NOS mRNA and proteins were proportionally increased in the right ventricle, but not in the left ventricle. These results suggest that the expression of NOS is specifically increased in association with the ventricular hypertrophy, which may be a mechanism counteracting the hypertrophy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: RNA Mensageiro / Western Blotting / Monocrotalina / Hipertrofia Ventricular Direita / Cardiomegalia / Óxido Nítrico Sintase / Coração / Ventrículos do Coração / Hipertrofia / Óxido Nítrico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: RNA Mensageiro / Western Blotting / Monocrotalina / Hipertrofia Ventricular Direita / Cardiomegalia / Óxido Nítrico Sintase / Coração / Ventrículos do Coração / Hipertrofia / Óxido Nítrico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2001 Tipo de documento: Artigo