Regulation of Ca2+ Signaling in Pulmonary Hypertension
The Korean Journal of Physiology and Pharmacology
;
: 1-8, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-728179
ABSTRACT
Understanding the cellular and molecular mechanisms involved in the development and progression of pulmonary hypertension (PH) remains imperative if we are to successfully improve the quality of life and life span of patients with the disease. A whole plethora of mechanisms are associated with the development and progression of PH. Such complexity makes it difficult to isolate one particular pathway to target clinically. Changes in intracellular free calcium concentration, the most common intracellular second messenger, can have significant impact in defining the pathogenic mechanisms leading to its development and persistence. Signaling pathways leading to the elevation of [Ca2+]cyt contribute to pulmonary vasoconstriction, excessive proliferation of smooth muscle cells and ultimately pulmonary vascular remodeling. This current review serves to summarize the some of the most recent advances in the regulation of calcium during pulmonary hypertension.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Qualidade de Vida
/
Vasoconstrição
/
Sistemas do Segundo Mensageiro
/
Cálcio
/
Miócitos de Músculo Liso
/
Concentração de Íons de Hidrogênio
/
Hipertensão Pulmonar
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2013
Tipo de documento:
Artigo
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