Increased response of hypogastric nerve fibers to bradykinin by mustard oil-induced uterine inflammation in the rat
The Korean Journal of Physiology and Pharmacology
;
: 99-105, 2001.
Artigo
em Inglês
| WPRIM
| ID: wpr-728228
ABSTRACT
It is well known that the inflammation of somatic tissues, bladder and colon can alter the sensitivity of primary afferents innervating these tissues. To see if uterine afferents also show altered sensitivity, we examined their responses to the algesic agent bradykinin before and after induction of uterine inflammation. Inflammation was induced by injecting the mustard oil into the uterine lumen of adult female rats. After induction of inflammation, the response latency to bradykinin did not change, but the duration and peak of the response and integrated impulse discharges during the response period increased significantly. Furthermore, after inflammation, the level of resting discharges of the afferents was much higher. These results are consistent with the idea that the inflammation can sensitize the uterine afferents.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Reação
/
Útero
/
Bexiga Urinária
/
Bradicinina
/
Colo
/
Inflamação
/
Mostardeira
/
Fibras Nervosas
Limite:
Animais
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2001
Tipo de documento:
Artigo
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