Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats
The Korean Journal of Physiology and Pharmacology
;
: 293-297, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-728276
ABSTRACT
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50 microgram/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition, they showed increased 5-HT1A receptor densities in the cerebral cortex. Pretreatment with 8-OH-DPAT ameliorated the behavioral and neurochemical sequelae measured in the present study. The results suggest that 5-HT1A receptors protect the brain from ischemic insult and/or facilitate recovery after prenatally experienced ischemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Serotonina
/
Cerebelo
/
Córtex Cerebral
/
8-Hidroxi-2-(di-n-propilamino)tetralina
/
Fármacos Neuroprotetores
/
Receptor 5-HT1A de Serotonina
/
Agonistas do Receptor 5-HT1 de Serotonina
/
Isquemia
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2002
Tipo de documento:
Artigo
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