Effects of norepinephrine and neuropeptide Y on the contractility of small mesenteric artery from 2K1C and DOCA-salt hypertensive rats
The Korean Journal of Physiology and Pharmacology
;
: 55-61, 2000.
Artigo
em Inglês
| WPRIM
| ID: wpr-728338
ABSTRACT
The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA-salt hypertension were made in Sprague-Dawley rats. Four weeks after induction of hypertension, systolic blood pressure measured in conscious state was significantly higher in 2K1C (216+/-18 mmHg) and DOCA-salt (205+/-29 mmHg) groups than that in control (128+/-4 mmHg). The third branches (<300 micrometer in outer diameter) of the mesenteric artery were isolated and cut into ring segments of 2apprx3 mm in length. Each ring segment was mounted in tissue bath and connected to a force displacement transducer for measurement of isometric tension. The arterial rings were contracted by application of norepinephrine (NE) in a dose-dependent manner. The amplitude of the NE-induced contraction of the vessels was significantly larger in hypertension than in control. The NE-induced contraction was significantly enhanced by neuropeptide Y (NPY) in hypertension. Reciprocally, NPY-elicited vasocontraction was increased by NE in hypertension. These results suggest that the sympathetic nervous system contributes to the development of 2K1C and DOCA-salt hypertension.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema Nervoso Simpático
/
Transdutores
/
Banhos
/
Pressão Sanguínea
/
Neuropeptídeo Y
/
Neuropeptídeos
/
Norepinefrina
/
Ratos Sprague-Dawley
/
Desoxicorticosterona
/
Hipertensão
Limite:
Animais
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2000
Tipo de documento:
Artigo
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