Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain
The Korean Journal of Physiology and Pharmacology
;
: 69-74, 1999.
Artigo
em Inglês
| WPRIM
| ID: wpr-728429
ABSTRACT
Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using (35S)UTP-labeled antisense c-fos, cRNA increased c-fos mRNA levels though hippocampal formation, piriform cortex, septum, caudate-putamen, neostriatum, and amygdala within 2 hr. In parallel with the mRNA expression, c-FOS protein immunoreactivity was also observed in the same forebrain areas. In contrast to the seizure activity and widespread neuronal degeneration following a kainate treatment, injections of lidocaine did not produce neuronal death within 3 days. The present study indicates that lidocaine induces convulsion and c-fos expression without causing neuro-toxicity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Convulsões
/
Fatores de Transcrição
/
Encéfalo
/
RNA Mensageiro
/
Prosencéfalo
/
Neostriado
/
Hibridização In Situ
/
RNA Complementar
/
Hipocampo
/
Tonsila do Cerebelo
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
1999
Tipo de documento:
Artigo
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