Anti-ischemic Effect of Polygala Tenuifolia in Isolated Rat Heart
The Korean Journal of Physiology and Pharmacology
;
: 89-95, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-728482
ABSTRACT
Polygala tenuifolia (PT) is one of the most well-known traditional herbal medicines in Korea which is commonly used for the treatment of cardiovascular symptoms. The anti-ischemic effects of PT in isolated rat heart was investigated by analyzing changes in blood pressure, aortic flow, coronary flow, and cardiac output. And, its underlying mechanism was examined by quantitating intracellular calcium content in rat neonatal cardiomyocytes. Rats were divided into two groups an ischemia-induced group without any treatment, and an ischemia-induced group treated with PT. Ischemia of isolated heart was induced by stopping the supply of oxygen and buffer for 10 min. The isolated heart was exposed to PT for the first 5 min of 10 min ischemia. PT treatment significantly prevented the decreases of perfusion pressure, aortic flow, coronary flow, and cardiac output under ischemic conditions. In addition, hemodynamics (except heart rate) of the PT-treated group was significantly recovered 60 min after reperfusion compared to the control group (systolic aortic pressure 83.3% vs. 64.9%, aortic flow volume 69.5% vs. 48.7%, coronary flow volume 77.7% vs. 58.4%, and cardiac output 71.6% vs. 51.2%, p<0.01). As for the underlying mechanism, PT significantly prevented intracellular calcium increase which was induced by isoproterenol (p<0.01), suggesting that the anti-ischemic effect of PT is mediated by inhibition of intracellular calcium increase.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Perfusão
/
Débito Cardíaco
/
Reperfusão
/
Cálcio
/
Miócitos Cardíacos
/
Polygala
/
Pressão Arterial
/
Coração
/
Hemodinâmica
Limite:
Animais
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2007
Tipo de documento:
Artigo
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