Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms
The Korean Journal of Physiology and Pharmacology
;
: 145-152, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-728585
ABSTRACT
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce cardioprotection. Indeed, RIPC-induced cardioprotective effects are reliant on the presence of intact neuronal pathways, which has been confirmed using nerve resection of nerves including femoral nerve, vagus nerve, and sciatic nerve. The involvement of neurogenic signaling has been further substantiated using various pharmacological modulators including hexamethonium and trimetaphan. The present review focuses on the potential involvement of neurogenic pathways in mediating remote ischemic preconditioning-induced cardioprotection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células Receptoras Sensoriais
/
Nervo Isquiático
/
Trimetafano
/
Nervo Vago
/
Encéfalo
/
Negociação
/
Hexametônio
/
Precondicionamento Isquêmico
/
Nervo Femoral
/
Miocárdio
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2017
Tipo de documento:
Artigo
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