Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway
The Korean Journal of Physiology and Pharmacology
;
: 533-538, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-728677
ABSTRACT
Angiogenesis plays an essential role in embryo development, tissue repair, inflammatory diseases, and tumor growth. In the present study, we showed that endothelial nitric oxide synthase (eNOS) regulates retinal angiogenesis. Mice that lack eNOS showed growth retardation, and retinal vessel development was significantly delayed. In addition, the number of tip cells and filopodia length were significantly reduced in mice lacking eNOS. Retinal endothelial cell proliferation was significantly blocked in mice lacking eNOS, and EMG-2-induced endothelial cell sprouting was significantly reduced in aortic vessels isolated from eNOS-deficient mice. Finally, pericyte recruitment to endothelial cells and vascular smooth muscle cell coverage to blood vessels were attenuated in mice lacking eNOS. Taken together, we suggest that the endothelial cell function and blood vessel maturation are regulated by eNOS during retinal angiogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pseudópodes
/
Retina
/
Vasos Retinianos
/
Retinaldeído
/
Vasos Sanguíneos
/
Transdução de Sinais
/
Pericitos
/
Células Endoteliais
/
Desenvolvimento Embrionário
/
Óxido Nítrico Sintase Tipo III
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2016
Tipo de documento:
Artigo
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