The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells
The Korean Journal of Physiology and Pharmacology
; : 555-563, 2017.
Article
em En
| WPRIM
| ID: wpr-728757
Biblioteca responsável:
WPRO
ABSTRACT
Electrical stimulation through retinal prosthesis elicits both short and long-latency retinal ganglion cell (RGC) spikes. Because the short-latency RGC spike is usually obscured by electrical stimulus artifact, it is very important to isolate spike from stimulus artifact. Previously, we showed that topographic prominence (TP) discriminator based algorithm is valid and useful for artifact subtraction. In this study, we compared the performance of forward backward (FB) filter only vs. TP-adopted FB filter for artifact subtraction. From the extracted retinae of rd1 mice, we recorded RGC spikes with 8×8 multielectrode array (MEA). The recorded signals were classified into four groups by distances between the stimulation and recording electrodes on MEA (200-400, 400-600, 600-800, 800-1000 µm). Fifty cathodic phase-1(st) biphasic current pulses (duration 500 µs, intensity 5, 10, 20, 30, 40, 50, 60 µA) were applied at every 1 sec. We compared false positive error and false negative error in FB filter and TP-adopted FB filter. By implementing TP-adopted FB filter, short-latency spike can be detected better regarding sensitivity and specificity for detecting spikes regardless of the strength of stimulus and the distance between stimulus and recording electrodes.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Retina
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Células Ganglionares da Retina
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Retinaldeído
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Sensibilidade e Especificidade
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Artefatos
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Estimulação Elétrica
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Eletrodos
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Próteses Visuais
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2017
Tipo de documento:
Article