Renal Tubular Acidosis in Cadmium-Intoxicated Rats
The Korean Journal of Physiology and Pharmacology
;
: 41-46, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-728771
ABSTRACT
Effect of cadmium (Cd) intoxication on renal acid-base regulation was studied in adult male Sprague-Dawley rats. Cd intoxication was induced by subcutaneous injections of CdCl2 at a dose of 2 mg Cd/kg/day for 3-4 weeks. In Cd-intoxicated animals, arterial pH, PCO2 and plasma bicarbonate concentration decreased, showing a metabolic acidosis. Urine pH and urinary bicarbonate excretion increased and titratable acid excretion decreased with no change in ammonium excretion. In renal cortical brush-border membrane vesicles derived from Cd-exposed animals, the Na /H antiporter activity was significantly attenuated. These results indicate that chronic exposures to Cd impair the proximal tubular mechanism for H secretion (i.e., Na /H antiport), leading to a metabolic acidosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Acidose
/
Acidose Tubular Renal
/
Cádmio
/
Ratos Sprague-Dawley
/
Transporte de Íons
/
Cloreto de Cádmio
/
Compostos de Amônio
/
Concentração de Íons de Hidrogênio
/
Injeções Subcutâneas
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2002
Tipo de documento:
Artigo
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