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Effect of kainic acid on the phosphorylation of mitogen activated protein kinases in rat hippocampus
The Korean Journal of Physiology and Pharmacology ; : 451-456, 2001.
Artigo em Inglês | WPRIM | ID: wpr-728786
ABSTRACT
In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide (CHX; 5 mg/kg; i.p.) inhibited KA-induced increase of p-JNK1, but not p-ERK1/2. Surprisingly, the phosphorylated upstream MAP kinase kinases (p-MKKs) were not correlated with their downstream MAP kinases. The basal p-MKK1/2 levels were completely abolished by KA, which were reversed by CHX. In addition, p-MKK4 and p-MKK3/6 levels were enhanced by CHX alone, but were attenuated by KA. Thus, our results showed that KA increased the p-ERK and p-JNK levels in rat hippocampus, which were not parallel with their classical upstreamal kinases.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosforilação / Fosfotransferases / Quinases de Proteína Quinase Ativadas por Mitógeno / Proteínas Quinases Ativadas por Mitógeno / Cicloeximida / Hipocampo / Ácido Caínico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2001 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fosforilação / Fosfotransferases / Quinases de Proteína Quinase Ativadas por Mitógeno / Proteínas Quinases Ativadas por Mitógeno / Cicloeximida / Hipocampo / Ácido Caínico Limite: Animais Idioma: Inglês Revista: The Korean Journal of Physiology and Pharmacology Ano de publicação: 2001 Tipo de documento: Artigo