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Etiological Classification and Developmental Outcomes in Floppy Infants: A Single Tertiary Center Experience / 대한소아신경학회지
Journal of the Korean Child Neurology Society ; (4): 189-196, 2018.
Artigo em Inglês | WPRIM | ID: wpr-728822
ABSTRACT

PURPOSE:

Floppy infants or congenital hypotonia indicates decreased muscle tone in infants secondary to abnormalities of the central or the peripheral nervous system, or both. Previous literature classified its causes as those attributable to a central vs. peripheral origin; however, recent studies have introduced a newer classification describing a combined origin. We invenstigated floppy infants by applying the new etiological classification and reviewed the most common etiologies based on the age of presentation. We additionally reviewed the clinical characteristics, diagnoses, and the developmental outcomes in these infants.

METHODS:

We retrospectively reviewed the electronic medical charts and recruited 116 infants diagnosed with floppy infant syndrome between January 2005 and December 2016 at Severance Children's Hospital. Among these infants, 66 with a confirmed diagnosis were reviewed for the etiological classification. Information regarding developmental outcomes was obtained via phone interviews with the infants' families.

RESULTS:

Based on the new etiological classification, among 69 infants with a confirmed diagnosis, in 40 (34.5%) this syndrome was of central origin, in 19 (16.4%) of peripheral origin, and in 10 (8.6%) of combined origin. Prader-Willi syndrome, myotonic dystrophy, and spinal muscular atrophy were the most common disorders observed and combined hypotonia showed the poorest developmental outcome.

CONCLUSION:

The study states the importance of proper evaluation of etiological diagnosis and optimal intervention for developmental prognosis. The introduction of a new etiological group of combined hypotonia especially emphasizes regular monitoring and timely rehabilitative intervention in patients for the better quality of life in them as well as their caregivers.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome de Prader-Willi / Prognóstico / Qualidade de Vida / Atrofia Muscular Espinal / Estudos Retrospectivos / Classificação / Cuidadores / Sistema Nervoso Periférico / Diagnóstico / Hipotonia Muscular Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo prognóstico Limite: Humanos / Lactente Idioma: Inglês Revista: Journal of the Korean Child Neurology Society Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Síndrome de Prader-Willi / Prognóstico / Qualidade de Vida / Atrofia Muscular Espinal / Estudos Retrospectivos / Classificação / Cuidadores / Sistema Nervoso Periférico / Diagnóstico / Hipotonia Muscular Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo prognóstico Limite: Humanos / Lactente Idioma: Inglês Revista: Journal of the Korean Child Neurology Society Ano de publicação: 2018 Tipo de documento: Artigo