Optimization of Culturing Conditions for Improved Production of Bioactive Metabolites by Pseudonocardia sp. VUK-10
Mycobiology
;
: 174-181, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-729388
ABSTRACT
The purpose of the present study was to investigate the influence of cultural and environmental parameters affecting the growth and bioactive metabolite production of the rare strain VUK-10 of actinomycete Pseudonocardia, which exhibits a broad spectrum of in vitro antimicrobial activity against bacteria and fungi. Production of bioactive metabolites by the strain was high the in modified yeast extract-malt extract-dextrose (ISP-2) broth, as compared to other tested media. Glucose (1%) and tryptone (0.25%) were found to be the most suitable carbon and nitrogen sources, respectively, for optimum production of growth and bioactive metabolites. Maximum production of bioactive metabolites was found in the culture medium with initial pH 7 incubated with the strain for four days at 30degrees C, under shaking conditions. This is the first report on the optimization of bioactive metabolites by Pseudonocardia sp. VUK-10.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Entorses e Distensões
/
Bactérias
/
Leveduras
/
Carbono
/
Fungos
/
Glucose
/
Concentração de Íons de Hidrogênio
/
Nitrogênio
Idioma:
Inglês
Revista:
Mycobiology
Ano de publicação:
2011
Tipo de documento:
Artigo
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