Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius
Mycobiology
;
: 117-120, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-729443
ABSTRACT
During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (¹H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC₅₀ values in the range of 0.7~8.1 µM.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Orthomyxoviridae
/
Prótons
/
Espectroscopia de Ressonância Magnética
/
Cromatografia
/
Metanol
/
Frutas
/
Fungos
/
Neuraminidase
Idioma:
Inglês
Revista:
Mycobiology
Ano de publicação:
2016
Tipo de documento:
Artigo
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