Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus
Mycobiology
;
: 158-162, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-730054
ABSTRACT
The immunomodulatory effect of aqueous extract of Inonotus obliquus, called as Chaga, was tested on bone marrow cells from chemically immunosuppressed mice. The Chaga water extract was daily administered for 24 days to mice that had been treated with cyclophosphamide (400 mg/kg body weight), immunosuppressive alkylating agent. The number of colony-forming unit (CFU)-granulocytes/macrophages (GM) and erythroid burst-forming unit (BFU-E), increased almost to the levels seen in non-treated control as early as 8 days after treatment. Oral administration of the extract highly increased serum levels of IL-6. Also, the level of TNF-alpha was elevated by the chemical treatment in control mice, whereas was maintained at the background level in the extract-treated mice, indicating that the extract might effectively suppress TNF-alpha related pathologic conditions. These results strongly suggest the great potential of the aqueous extract from Inonotus obliquus as immune enhancer during chemotherapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco
/
Medula Óssea
/
Células da Medula Óssea
/
Água
/
Células Precursoras Eritroides
/
Administração Oral
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
/
Ciclofosfamida
/
Agaricales
Limite:
Animais
Idioma:
Inglês
Revista:
Mycobiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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