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Acetazolamide-Challenged Brain CT Perfusion before and after Carotid Stenting / 신경중재치료의학
Neurointervention ; : 107-115, 2009.
Artigo em Inglês | WPRIM | ID: wpr-730347
ABSTRACT

PURPOSE:

To test hypothesis that pre-stenting measurement of reactivity index by using acetazolamide-challenged CT perfusion could identify patients at risk for hyperperfusion after carotid stenting. MATERIALS AND

METHODS:

For 24 regions of interest in 12 patients with symptomatic unilateral high-grade carotid stenosis, asymmetric indexes for cerebral blood volume, cerebral blood flow, and mean transit time and reactivity index were calculated from resting and acetazolamide-challenged CT perfusion before and 1 day after carotid stenting. We subsequently compared pre-stenting asymmetric indexes and reactivity index with percent increase of cerebral blood flow 1 day after carotid stenting.

RESULTS:

Percent increase of cerebral blood flow on the first post-stenting day was not significantly different between visually decreased and normal cerebrovascular reserve groups. There was no significant correlation between pre-stenting asymmetric indexs of resting CT perfusion parameters and percent increase of cerebral blood flow 1 day after carotid stenting. On the other hand, pre-stenting reduction of reactivity index showed fair correlation with 1 day cerebral blood flow increase. However, hyperperfusion or hyperperfusion syndrome was not observed in any patient with reduced reactivity index.

CONCLUSION:

Pre-stenting measurements of resting CT perfusion parameters and reactivity index could not predict hyperperfusion after carotid stenting. However, pre-stenting reduction of reactivity index seems to fairly correlate with immediate post-stenting cerebral blood flow increase. Further studies with larger population should be performed to validate this preliminary result.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Volume Sanguíneo / Encéfalo / Stents / Estenose das Carótidas / Mãos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Neurointervention Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Volume Sanguíneo / Encéfalo / Stents / Estenose das Carótidas / Mãos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Neurointervention Ano de publicação: 2009 Tipo de documento: Artigo