Study on the relationship between panel reactive antibody and long-term prognosis of transplant renal function / 器官移植

ABSTRACT

Objective To study the impact of panel reactive antibody (PRA)on the long-term prognosis of transplant renal function after renal transplantation.Methods The objects of this study were 224 patients,who underwent renal transplantation,received PRA test about 2 weeks after operation and followed up in Affiliated Beijing Friendship Hospital of Capital Medical University from January 1 994 to December 2004.According to the PRA test results,the patients were divided into two groupsnegative group (n =1 95)and positive group (n =29).PRA of patients in negative group were tested again in 2007.Serum creatinine (Scr) of patients in both groups were tested recently (from October 201 3 to April 201 4)to know about the renal function.The rates of long-term normal transplant renal function between PRA positive patients (including PRA re-test positive patients)and PRA negative patients were compared.Results In 29 cases of positive group, the re-test result in April 201 4 showed that 1 8 cases were observed with loss (n =1 7)or decline (n =1 )of renal function,and 1 1 cases were observed with normal renal function.In 1 95 cases of negative group,a total of 1 53 cases were re-tested with PRA negative in 2007,1 48 cases were re-tested with normal renal function in April 201 4,and 5 cases were observed with decline or loss of renal function.A total of 42 cases were re-tested with PRA positive in 2007 and the transplant renal function was observed decline or loss by varying degrees.There were a total of 71 cases with PRA positive before 2004 and when re-tested in 2007,and 1 1 cases were re-tested with normal renal function in April 201 4.The rate of long-term normal transplant renal function was 1 5.5%.There were 1 53 cases with PRA negative and 1 48 cases were re-tested with normal renal function in April 201 4.The rate of long-term normal transplant renal function was 96.7%.Significant difference was observed in the rates of long-term normal transplant renal function between PRA positive patients and PRA negative patients (P <0.005).Conclusions PRA after renal transplantation has obvious impacts on the long-term prognosis of transplant renal function.